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CAS No.: 58-85-5

生物素 Catalog No. CSN23623

Synonyms: 生物素;Vitamin B7;Vitamin H

Biotin, also known as vitamin B7, is necessary for cell growth and production of fatty acids. It can be used to elute proteins from avidin-streptavidin resins.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Biotin is a water-soluble B-complex vitamin and is well-known as a co-factor for 5 indispensable carboxylases. Biotin regulates immunological and inflammatory functions independently of biotin-dependent carboxylases. An in-vivo analysis with a murine model revealed the therapeutic effects of biotin supplementation on metal allergies^[2]. Biotin is a water-soluble vitamin required by all organisms by virtue of its essential role in carboxylation reactions. Additionally, the potential role of biotin in the regulation of gene expression has been strengthened through description of altered gene expression during biotin deficiency and through newly described enzymatic activities of the enzyme biotinidase^[3]. Daily oral supplementation with 1 mg of biotin resulted in dramatic improvement of the periorificial dermatitis and hair growth together with a complete disappearance of the organic aciduria^[4]. Biotin is rapidly metabolized and excreted in urine. Little acute oral toxicity is seen in animal tests. Short-term and subchronic toxicity studies likewise found no evidence of toxicity. Although intradermal injection of a small quantity of Biotin (0.1 ml) into guinea pig skin did not produce skin irritation, Biotin (0.1% at pH 7.3) did produce slight, transient ocular irritation in rabbit eyes. There was evidence of an increase in the number of resorptions in rats receiving Biotin by subcutaneous injection, with concomitant decreases in fetal, uterine, and placental weights^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0932 mL
- 20.4658 mL
- 40.9316 mL
- 5 mM
- 0.8186 mL
- 4.0932 mL
- 8.1863 mL
- 10 mM
- 0.4093 mL
- 2.0466 mL
- 4.0932 mL

技术信息

CAS号

58-85-5

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H16N2O3S

运输

蓝冰

分子量

244.31

别名

生物素;Vitamin B7;Vitamin H;D-Biotin

溶解度

DMSO	1250.0 mg/mL (5116.4 mM)
Water	insoluble

动物实验配方

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